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| Title |
The Role of Innate Immunity in Osteoarthritis: When Our First Line of Defense Goes On the Offensive
|
|---|---|
| Published in |
Journal of Rheumatology, January 2015
|
| DOI | 10.3899/jrheum.140382 |
| Pubmed ID | |
| Authors |
Eric W Orlowsky, Virginia Byers Kraus |
| Abstract |
Although osteoarthritis (OA) has existed since the dawn of humanity, its pathogenesis remains poorly understood. OA is no longer considered a "wear and tear" condition but rather one driven by proteases where chronic low-grade inflammation may play a role in perpetuating proteolytic activity. While multiple factors are likely active in this process, recent evidence has implicated the innate immune system, the older or more primitive part of the body's immune defense mechanisms. The roles of some of the components of the innate immune system have been tested in OA models in vivo including the roles of synovial macrophages and the complement system. This review is a selective overview of a large and evolving field. Insights into these mechanisms might inform our ability to identify patient subsets and give hope for the advent of novel OA therapies. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 11 | 14% |
| United Kingdom | 6 | 8% |
| Canada | 3 | 4% |
| New Zealand | 1 | 1% |
| Norway | 1 | 1% |
| Taiwan | 1 | 1% |
| Spain | 1 | 1% |
| Russia | 1 | 1% |
| Australia | 1 | 1% |
| Other | 2 | 3% |
| Unknown | 48 | 63% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 57 | 75% |
| Practitioners (doctors, other healthcare professionals) | 12 | 16% |
| Scientists | 6 | 8% |
| Science communicators (journalists, bloggers, editors) | 1 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 269 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | <1% |
| Denmark | 1 | <1% |
| Italy | 1 | <1% |
| Norway | 1 | <1% |
| Unknown | 265 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 37 | 14% |
| Researcher | 32 | 12% |
| Student > Bachelor | 30 | 11% |
| Student > Master | 27 | 10% |
| Other | 22 | 8% |
| Other | 44 | 16% |
| Unknown | 77 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 53 | 20% |
| Biochemistry, Genetics and Molecular Biology | 47 | 17% |
| Agricultural and Biological Sciences | 20 | 7% |
| Immunology and Microbiology | 13 | 5% |
| Engineering | 12 | 4% |
| Other | 38 | 14% |
| Unknown | 86 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 51. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2023.
All research outputs
#870,723
of 26,184,649 outputs
Outputs from Journal of Rheumatology
#39
of 4,048 outputs
Outputs of similar age
#11,413
of 381,585 outputs
Outputs of similar age from Journal of Rheumatology
#2
of 73 outputs
Altmetric has tracked 26,184,649 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,048 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 381,585 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 73 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.