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The Journal of Rheumatology

The Role of Innate Immunity in Osteoarthritis: When Our First Line of Defense Goes On the Offensive

Overview of attention for article published in Journal of Rheumatology, January 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#36 of 3,951)
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

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77 X users
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1 patent
facebook
4 Facebook pages

Citations

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205 Dimensions

Readers on

mendeley
263 Mendeley
Title
The Role of Innate Immunity in Osteoarthritis: When Our First Line of Defense Goes On the Offensive
Published in
Journal of Rheumatology, January 2015
DOI 10.3899/jrheum.140382
Pubmed ID
Authors

Eric W Orlowsky, Virginia Byers Kraus

Abstract

Although osteoarthritis (OA) has existed since the dawn of humanity, its pathogenesis remains poorly understood. OA is no longer considered a "wear and tear" condition but rather one driven by proteases where chronic low-grade inflammation may play a role in perpetuating proteolytic activity. While multiple factors are likely active in this process, recent evidence has implicated the innate immune system, the older or more primitive part of the body's immune defense mechanisms. The roles of some of the components of the innate immune system have been tested in OA models in vivo including the roles of synovial macrophages and the complement system. This review is a selective overview of a large and evolving field. Insights into these mechanisms might inform our ability to identify patient subsets and give hope for the advent of novel OA therapies.

X Demographics

X Demographics

The data shown below were collected from the profiles of 77 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 263 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 <1%
Denmark 1 <1%
Italy 1 <1%
Norway 1 <1%
Unknown 259 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 37 14%
Researcher 32 12%
Student > Bachelor 30 11%
Student > Master 26 10%
Other 22 8%
Other 47 18%
Unknown 69 26%
Readers by discipline Count As %
Medicine and Dentistry 53 20%
Biochemistry, Genetics and Molecular Biology 46 17%
Agricultural and Biological Sciences 20 8%
Immunology and Microbiology 13 5%
Engineering 10 4%
Other 44 17%
Unknown 77 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 51. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2023.
All research outputs
#826,294
of 25,392,582 outputs
Outputs from Journal of Rheumatology
#36
of 3,951 outputs
Outputs of similar age
#11,148
of 377,540 outputs
Outputs of similar age from Journal of Rheumatology
#3
of 73 outputs
Altmetric has tracked 25,392,582 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,951 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 377,540 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 73 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.